Alfentanil: a study of its analgesic activity and interactions with morphine in the mouse.
نویسندگان
چکیده
Alfentanil has a short duration action which did not markedly increase with increasing dose in mice. It is approximately one-fourth as potent as fentanyl. Repeat injections gave reproducible analgesic effects but depression of respiratory rate increased when repeat injections were given on the basis of cessation of analgesic activity. Alfentanil appeared to reduce the analgesic effect of morphine given 30-60 min after alfentanil administration. This has been demonstrated with injection of alfentanil 15 min before, simultaneously with and 30 min after morphine injection. There were not significant effects on depression of respiratory rate produce by morphine.
منابع مشابه
Analgesic effect of Persian Gulf Conus textile venom
Objective(s):Cone snails are estimated to consist of up to 700 species. The venom of these snails has yielded a rich source of novel peptides. This study was aimed to study the analgesic effect of Persian Gulf Conus textile and its comparison with morphine in mouse model. Materials and Methods: Samples were collected in Larak Island. The venom ducts were Isolated and kept on ice then homogenize...
متن کاملRelationship between analgesia and respiratory depression for mu opioid receptor agonists in mice.
The relationship between analgesic activity, measured as the hot plate reaction time, and respiratory depression, measured as ventilatory frequency, was investigated in mice for a variety of mu opioid receptor agonists with differing selectivities for mu receptors compared with delta receptors. There was a weak correlation between analgesia and respiratory depression for opioids with the greate...
متن کاملInteraction between Analgesic Effect of Nano and Conventional size of Zinc Oxide and Opioidergic System Activity in Animal Model of Acute Pain
Introduction: Today Nano-medicine tries to produce new drugs to reduce the dosage and side effects of their conventional forms. According to the interaction between zinc and opioidergic system activity, this study has investigated the effect of new kind of zinc supplement, nano zinc oxide (nZnO), in compared to its conventional form (cZnO), in presence and absence of opioidergic system activity...
متن کاملارزیابی اثر دولوکستین بر علائم وابستگی به مورفین و تحمل به اثرات ضددردی آن در موش سوری
Background and Objectives: Despite the analgesic effects of morphine, its chronic use leads to tolerance and dependence, and duloxetine can change the rate of dependence and tolerance. This study aimed to investigate the effect of duloxetine on morphine-induced dependence and tolerance to its analgesic effects in mice. Materials and Methods: In the present experimental study, male mice were ra...
متن کاملAttenuation of Morphine Withdrawal Syndrome by Various Dosages of Curcumin in Comparison with Clonidine in Mouse: Possible Mechanism
Background: Herbal medical compounds and their major constituent have been used in the management and treatment of opioid withdrawal syndrome and pain. This study was carried out to clarify the effect of curcumin, the major compound of turmeric, on morphine withdrawal syndrome in mouse model and its possible mechanisms of pain relieving activity by assessing in writhing test as a model of visce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- British journal of anaesthesia
دوره 54 1 شماره
صفحات -
تاریخ انتشار 1982